Journal article

COLLATERAL DEVELOPMENT AND ANGIOGENESIS AFTER MAJOR ARTERY LIGATION DOES NOT ALTER HINDQUARTER VASCULAR REACTIVITY IN CONSCIOUS RABBITS

JE WARD, JA ANGUS

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | LIPPINCOTT-RAVEN PUBL | Published : 1995

Abstract

We tested whether vasodilator and vasoconstrictor responses of the hindquarter vasculature in conscious rabbits were altered 1 day, 2 weeks, and 6 months after bilateral superficial femoral artery ligation (SFAL). With pharmacological autonomic blockade, hindquarter flow (Doppler flowmeter) was restored to 84% of control values 1 day postligation (n = 5). Responses to aortic balloon inflation (5-80 s), and intraaortic infusion of norepinephrine, angiotensin II, serotonin, acetylcholine, sodium nitroprusside, and adenosine were similar to pre-SFAL responses. Two weeks post-SFAL, acrylic casts showed an extensive collateral network originating from branches of internal iliac and deep femoral a..

View full abstract

University of Melbourne Researchers