Journal article

COMPARISON OF CONTRACTILE RESPONSES TO 5-HYDROXYTRYPTAMINE AND SUMATRIPTAN IN HUMAN ISOLATED CORONARY-ARTERY - SYNERGY WITH THE THROMBOXANE A(2)-RECEPTOR AGONIST, U46619

TM COCKS, BK KEMP, D PRUNEAU, JA ANGUS

BRITISH JOURNAL OF PHARMACOLOGY | WILEY | Published : 1993

Abstract

1. The interaction between the thromboxane A2 receptor agonist, U46619 and two 5-hydroxytryptamine (5-HT) receptor agonists, the non-selective, naturally occurring agonist, 5-HT and the selective 5-HT1-like agonist, sumatriptan were studied in human epicardial coronary arteries in vitro. 2. Coronary artery rings (2-4 mm in diameter) were prepared from epicardial arteries from explant hearts of patients undergoing heart transplant (cardiomyopathy, n = 13; ischaemic heart disease, n = 10) and unused donor hearts (n = 5). Each ring of artery was set at optimal resting conditions to record changes in isometric force. 3. The majority of artery rings developed phasic, rhythmic contractions either ..

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