Journal article

EXPERIENCE WITH CALCIUM-ANTAGONISTS NITRENDIPINE, DILTIAZEM, AND VERAPAMIL AND BETA-2-AGONIST SALBUTAMOL IN SALVAGING ISCHEMIC SKIN FLAPS IN RABBITS

H KAWABATA, KR KNIGHT, SA COE, JA ANGUS, BM OBRIEN

MICROSURGERY | WILEY-LISS | Published : 1991

Abstract

This study investigated the efficacy of selected agents in the salvage of experimental skin flaps in rabbits after 21 hours of 25 degrees C ischemia. Calcium channel antagonists nitrendipine, diltiazem, and verapamil increased ischemic skin flap survival in rabbits from 33.3% for buffered saline infused controls to 71.4% (P less than 0.05), 71.4% (P less than 0.05), and 50.0% (not significant) respectively. The beta 2-adrenoceptor agonist salbutamol produced an increase in survival to 64.3%, which narrowly missed statistical significance. All four test agents invoked a vasodilatory response (greatest for nitrendipine, diltiazem, and salbutamol), a slight fall in blood pressure, and a small i..

View full abstract

University of Melbourne Researchers