Journal article

Central sympathoinhibition and peripheral neuronal uptake blockade after desipramine in rabbits.

G Eisenhofer, T Saigusa, MD Esler, HS Cox, JA Angus, PK Dorward

Am J Physiol | Published : 1991


Peripheral- and central nervous system (CNS)-mediated effects of desipramine (Des) on sympathetic nerves and the contribution of alpha 2-adrenoceptors to these effects were studied in conscious rabbits. Blood pressure, renal sympathetic nerve activity (SNA), and norepinephrine (NE) reuptake and spillover into plasma were measured before and after intracisternal (ic) or intravenous (i.v.) administration of Des. In other animals, NE spillover responses to i.v. Des were examined before and after alpha 2-adrenoceptor blockade with i.v. idazoxan. Treatment with i.v. Des blocked neuronal reuptake and decreased renal SNA but did not alter blood pressure or NE spillover. Decreased NE release by symp..

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University of Melbourne Researchers