Journal article

OMEGA-CONOTOXIN GVIA, THE N-TYPE CALCIUM-CHANNEL INHIBITOR, IS SYMPATHOLYTIC BUT NOT VAGOLYTIC - CONSEQUENCES FOR HEMODYNAMICS AND AUTONOMIC REFLEXES IN CONSCIOUS RABBITS

D PRUNEAU, JA ANGUS

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | LIPPINCOTT-RAVEN PUBL | Published : 1990

Abstract

We investigated the effects of the N-type calcium channel blocking agent, omega-conotoxin GVIA, on the resting hemodynamics and on some autonomic reflexes in the conscious rabbit. omega-Conotoxin 3 and 10 micrograms/kg i.v. reduced mean arterial blood pressure by 16 +/- 2 and 25 +/- 3 mm Hg, respectively, over 30 min accompanied by a tachycardia. Renal vascular conductance (Doppler flowmeter) increased by 27.6 +/- 3.7 and 38.6 +/- 10.3% at 30 min after omega-conotoxin 3 and 10 micrograms/kg, respectively. Vasodilatation was also observed but to a lesser extent in the hindquarter and mesenteric vascular beds. The baroreceptor-heart rate reflex was evoked by a drug method (bolus injection of s..

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