Amplifier function of resistance vessels and the left ventricle in hypertension

Abstract

We have recently modeled the structural factors responsible for the increased slope of the dose-vascular resistance response curves in the hindquarter bed under both in vitro and in vivo conditions. Slope increases when the ratio of wall thickness to internal radius ri) increases and when ri decreases, but the slope decreases with greater wall stiffness. Enhanced slope is an indicator of the vascular amplifier properties. Resistance at maximum vasodilation in hypertension is also structurally determined and is most affected by a reduction in riEarly treatment studies with angiotensin converting enzyme inhibitors in spontaneously hypertensive rats (SHR) suggest that the reduction in ri can be..