Journal article

OMEGA-CONOTOXIN GVIA IS A POTENT INHIBITOR OF SYMPATHETIC NEUROGENIC RESPONSES IN RAT SMALL MESENTERIC-ARTERIES

D PRUNEAU, JA ANGUS

BRITISH JOURNAL OF PHARMACOLOGY | STOCKTON PRESS | Published : 1990

Abstract

1. We have investigated the effects of the N-type calcium channel blocker, omega-conotoxin GVIA, on contractile responses to nerve stimulation, noradrenaline and KCl in rat small mesenteric arteries. In separate experiments, single and summated excitatory junctional potentials (e.j.ps) evoked by nerve stimulation were recorded with an intracellular electrode in the absence and presence of omega-conotoxin. 2. Electrical field stimulation of intramural sympathetic nerves (30 V; 0.25 ms pulse width; 3 s train length; 4-24 Hz) caused frequency-dependent contractions. Cumulative concentration-response curves for the contractions induced by noradrenaline and KCl were constructed in the same prepar..

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