Journal article

COMPARISON OF RELAXATION RESPONSES OF VASCULAR AND NONVASCULAR SMOOTH-MUSCLE TO ENDOTHELIUM-DERIVED RELAXING FACTOR (EDRF), ACIDIFIED SODIUM-NITRITE (NO) AND SODIUM-NITROPRUSSIDE

TM COCKS, JA ANGUS

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | SPRINGER VERLAG | Published : 1990

Abstract

Smooth muscle relaxant activity of endothelium-derived relaxing factor (EDRF) released from columns of cultured bovine endothelial cells by bradykinin (0.1-3 nmol/l) was measured in four non-vascular preparations: guinea-pig taenia caeci, guinea-pig trachea, rat stomach (fundus) and rat anococcygeus. Each preparation was contracted to a steady level of force with a variety of agonists such that they relaxed optimally to sodium nitroprusside (SNP). The EDRF-induced relaxations in each preparation were compared with those obtained in de-endothelialized ring preparations of greyhound coronary artery by means of paired bioassays run in parallel. EDRF released from the endothelial cell columns ca..

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University of Melbourne Researchers