Journal article

STUDIES ON THE SPECIFICITY OF THE INHIBITORY-ACTION OF N,N-DIISOPROPYL-N'-ISOAMYL-N'-DIETHYLAMINOETHYLUREA (P-286) ON ADRENAL CATECHOLAMINE RELEASE IN THE ANESTHETIZED RAT

E MALTA, JA ANGUS

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | BLACKWELL SCIENCE | Published : 1988

Abstract

1. The ability of P-286 (N,N-diisopropyl-N'-isoamyl-N'-diethylaminoethylurea) to reduce selectively the release of catecholamines from the adrenal medulla has been studied in urethane-anaesthetized rats. 2. Pressor responses to acetylcholine (Ach) and the nicotinic receptor-agonist 1,4-dimethylphenylpiperazine (DMPP) in rats treated with atropine, (+/-)-propranolol and guanethidine were used as the index of adrenal catecholamine release. 3. The injection of P-286 (1-10 mg/kg, i.v.) elicited a dose-dependent bradycardia which was associated with hypotension. P-286 reduced pressor responses to Ach and DMPP in a dose-dependent manner with an IC50 of 2.5 mg/kg and, following near complete blocka..

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