Journal article

CONTRIBUTION OF STENOSIS RESISTANCE TO THE RISE IN TOTAL PERIPHERAL RESISTANCE DURING EXPERIMENTAL RENAL-HYPERTENSION IN CONSCIOUS DOGS

WP ANDERSON, PI KORNER, JA ANGUS, CI JOHNSTON

CLINICAL SCIENCE | PORTLAND PRESS | Published : 1981

Abstract

1. Mild, moderate and severe renal artery stenosis was induced by uninephrectomized conscious dogs by inflating a renal artery cuff to lower distal pressure to 60, 40 or 20 mmHg respectively. The renal artery was narrowed progressively over the next 3 days by further inflation of the cuff to relower the distal renal artery pressure to the initial values. 2. Graded progressive stenosis produced graded progressive rises in blood pressure, plasma renin activity and total renal resistance to flow over the 3 day period, following by a return to control values 24 h after deflation. 3. The rise in total renal resistance to flow was almost entirely due to the stenosis, with only small changes occurr..

View full abstract

University of Melbourne Researchers