Journal article

COMPARISON OF CARDIOVASCULAR EFFECTS OF PROSCILLARIDIN AND OUABAIN IN ANESTHETIZED DOGS

JA ANGUS, DR RICHMOND, LB COBBIN, AH GOODMAN

AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE | ADIS PRESS AUSTRALASIA P/L | Published : 1973

Abstract

Summary: The activities of ouabain and proscillaridin (20, erg/kg) were compared in the dog. The two glycosides produced equal positive inotropic effects, a peak increase of myocardial contractility of approximately 20% being recorded at 20 to 30 minutes after their administration and for a further 30 minutes thereafter. Both drugs produced small immediate increases in systemic arterial blood pressure which fell below control levels 30 minutes after ouabain, and at a slower rate after proscillaridin. The bradycardia produced by ouabain was approximately twice that following proscillaridin. Both glycosides produced insignificant in‐creases in the PR interval and no difference on AV conduction..

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University of Melbourne Researchers