Cardiovascular actions of substituted adenosine analogues

Abstract

The effects of adenosine on systemic blood pressure, coronary blood flow and cardiac contractility and rate were studied in anaesthetized open‐thorax dogs. The potency and duration of action of substituted adenosine analogues were compared with that of adenosine. With the exception of 2‐chloroadenosine, in which coronary dilator activity was enhanced, substitution in the 2‐position of the adenosine molecule reduced activity. In all cases 2‐substitution prolonged the duration of the coronary dilator activity of adenosine. N6‐Methylation of adenosine and 2‐chloroadenosine reduced their coronary dilator activities, but had no effect on the duration of the response. Comparison of the coronary di..