Journal article

ANTI-TNF THERAPY INHIBITS FEVER IN CEREBRAL MALARIA

D KWIATKOWSKI, ME MOLYNEUX, S STEPHENS, N CURTIS, N KLEIN, P POINTAIRE, M SMIT, R ALLAN, DR BREWSTER, GE GRAU, BM GREENWOOD

QUARTERLY JOURNAL OF MEDICINE | OXFORD UNIV PRESS UNITED KINGDOM | Published : 1993

Abstract

The clinical effects of a murine monoclonal antibody (CB0006) directed against tumour necrosis factor were investigated in an open study of 41 Gambian children receiving otherwise conventional therapy for cerebral malaria. Ten children received a single i.v. dose of CB0006 at 0.1 mg/kg, 10 received 1 mg/kg, 10 received 5 mg/kg, and 11 were randomly selected as controls. CB0006 rapidly formed complexes with tumour necrosis factor, which were cleared from the circulation over several days. This was associated with a dose-dependent increase in total plasma tumour necrosis factor levels and a dose-dependent reduction of fever, implying that CB0006 inhibits tumour necrosis factor by retaining it ..

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