Journal article

The Warburg effect: molecular aspects and therapeutic possibilities

Ngo Hanh, Stephanie M Tortorella, Katherine Ververis, Tom C Karagiannis

MOLECULAR BIOLOGY REPORTS | SPRINGER | Published : 2015

Abstract

It has been about nine decades since the proposal of Otto Warburg on the metabolism of cancer cells. Unlike normal cells which undergo glycolysis and oxidative phosphorylation in the presence of oxygen, proliferating and cancer cells exhibit an increased uptake of glucose and increased rate of glycolysis and predominantly undergo lactic acid fermentation. Whether this phenomenon is the consequence of genetic dysregulation in cancer or is the cause of cancer still remains unknown. However, there is certainly a strong link between the genetic factors, epigenetic modulation, cancer immunosurveillance and the Warburg effect, which will be discussed in this review. Dichloroacetate and 3-bromopyru..

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University of Melbourne Researchers