Journal article

Development and evaluation of elastomeric hollow fiber membranes as small diameter vascular graft substitutes

Angel E Mercado-Pagan, Yunqing Kang, Michael W Findlay, Yunzhi Yang

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | ELSEVIER | Published : 2015

Abstract

Engineering of small diameter (<6mm) vascular grafts (SDVGs) for clinical use remains a significant challenge. Here, elastomeric polyester urethane (PEU)-based hollow fiber membranes (HFMs) are presented as an SDVG candidate to target the limitations of current technologies and improve tissue engineering designs. HFMs are fabricated by a simple phase inversion method. HFM dimensions are tailored through adjustments to fabrication parameters. The walls of HFMs are highly porous. The HFMs are very elastic, with moduli ranging from 1-4MPa, strengths from 1-5MPa, and max strains from 300-500%. Permeability of the HFMs varies from 0.5-3.5×10(-6)cm/s, while burst pressure varies from 25 to 35psi. ..

View full abstract

Grants

Awarded by NIH


Awarded by DOD


Awarded by NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES


Awarded by NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH


Funding Acknowledgements

We would like to acknowledge the financial support of the following agencies: NIH R01AR057837 (NIAMS), NIH R01DE021468 (NIDCR), and DOD W81XWH-10-1-0966 (PRORP). We would also like to thank Dr. Geoffrey C. Gurtner, from the Department of Plastic and Reconstructive Surgery at Stanford University, for his collaboration in this project. Finally, we are also grateful to Anthony Behn for his assistance in mechanical testing of samples, and Dr. Lydia-Marie Joubert from the Electron Microscopy Core at Stanford for use of, and assistance with, the Hitachi electron microscope.