Verifying likelihoods for low template DNA profiles using multiple replicates
Christopher D Steele, Matthew Greenhalgh, David J Balding
FORENSIC SCIENCE INTERNATIONAL-GENETICS | ELSEVIER IRELAND LTD | Published : 2014
To date there is no generally accepted method to test the validity of algorithms used to compute likelihood ratios (LR) evaluating forensic DNA profiles from low-template and/or degraded samples. An upper bound on the LR is provided by the inverse of the match probability, which is the usual measure of weight of evidence for standard DNA profiles not subject to the stochastic effects that are the hallmark of low-template profiles. However, even for low-template profiles the LR in favour of a true prosecution hypothesis should approach this bound as the number of profiling replicates increases, provided that the queried contributor is the major contributor. Moreover, for sufficiently many rep..View full abstract
Awarded by Biotechnology and Biological Sciences Research Council
CDS is funded by a PhD studentship from the UK Biotechnology and Biological Sciences Research Council and Cellmark Forensic Services.