Journal article
Clonidine restores pressor responsiveness to phenylephrine and angiotensin II in ovine sepsis
YR Lankadeva, LC Booth, J Kosaka, RG Evans, L Quintin, R Bellomo, CN May
Critical Care Medicine | Published : 2015
Abstract
Objectives: In sepsis, prolonged, sympathetic overstimulation may lead to vasopressor-refractory hypotension. We therefore examined the effects of the α2-adrenergic agonist clonidine on mean arterial pressure, renal sympathetic nerve activity, and pressor responsiveness to phenylephrine and angiotensin II during hypotensive sepsis in conscious sheep. Design: Interventional study. Setting: Research institute. Subjects: Twelve adult Merino ewes (n = 6 per group). Interventions: Sepsis was induced by IV infusion of Escherichia coli for 32 hours. Pressor responses to increasing doses of phenylephrine and angiotensin II were measured at baseline and at 24, 28, and 32 hours of sepsis. Sheep were t..
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Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
Supported, in part, by a grant from the National Health and Medical Research Council of Australia (1050672) and by funding from the Victorian Government Operational Infrastructure Support Grant.Dr. Lankadeva received grant support and disclosed employment. Dr. Booth is employed by the Florey Institute; received grant support from the University of Melbourne; and received support for travel from the Harold Mitchell Foundation, American Heart Association, and Federation of American Societies for Experimental Biology. Her institution received grant support from the National Health and Medical Research Council (NHMRC) of Australia. Dr. Kosaka's institution received grant support. Dr. Evans is employed by Monash University. His institution received grant support from the NHMRC of Australia. Dr. Quintin received support for article research from Centre National de la Recherche Scientifique Projet Exploratoire Premier Soutien grant and has patent (U.S. Patent issued to Dr. Quintin). His institution received grant support from CNRS. Dr. May was supported by a NHMRC Research Fellowship. Dr. May received grant support from the NHMRC of Australia, is employed by the Florey Institute of Neuroscience, lectured (honoraria and travel support for presentations from Medtronic), has a patent (patent for use of flavonols for cardiac injury), and received support for article research from NHMRC. His institution received grant support from the NHMRC. Dr. Bellomo has disclosed that he does not have any potential conflicts of interest.