Journal article
Predictors of disease severity in children hospitalized for pertussis during an epidemic
H Marshall, M Clarke, K Rasiah, P Richmond, J Buttery, G Reynolds, R Andrews, M Nissen, N Wood, P Mcintyre
Pediatric Infectious Disease Journal | Published : 2015
Abstract
Background: Australia recently experienced its worst pertussis epidemic since introduction of pertussis vaccine into the National Immunisation Program. This study aimed to determine factors associated with severe pertussis in hospitalized children during an epidemic using a novel pertussis severity scoring (PSS) system. Methods: This prospective, observational, multicenter study enrolled children hospitalized with laboratory confirmed pertussis from 8 tertiary pediatric hospitals during a 12 month period (May 2009-April 2010). Variables assessed included demographics, clinical symptoms and relevant medical and immunization history. Cases were scored using objective clinical findings with cas..
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Funding Acknowledgements
Helen Marshall, Peter Richmond, Michael Nissen, Nick Wood and Graham Reynolds have been investigators for studies funded by pharmaceutical companies including GSK and/or Sanofi-Pasteur. Travel support has been provided to their institutions by GSK and/or Sanofi-Pasteur for Jim Buttery, Helen Marshall, Peter Richmond, Michael Nissen, and Graham Reynolds to present scientific data at international meetings. In addition institutional funding or serological testing has been provided by GSK for investigator led epidemiological and vaccine safety studies conducted by Peter Richmond, Helen Marshall, Jim Buttery, Peter McIntyre and Nick Wood. The remaining authors have no funding or conflicts of interest to disclose.