Journal article
Novel porcine-like human G26P[19] rotavirus identified in hospitalized paediatric diarrhoea patients in Ho Chi Minh City, Vietnam
Vu Tra My Phan, Maia A Rabaa, Celeste Donato, Daniel Cowley, Vinh Phat Voong, Thi Ngoc Dung Iran, Hong Anh Pham, Vinh Ha, Juliet E Bryant, Paul Kellam, Guy Thwaites, Mark EJ Woolhouse, Carl D Kirkwood, Stephen Baker
JOURNAL OF GENERAL VIROLOGY | MICROBIOLOGY SOC | Published : 2014
Abstract
During a hospital-based diarrhoeal disease study conducted in Ho Chi Minh City, Vietnam from 2009 to 2010, we identified four symptomatic children infected with G26P[19] rotavirus (RV)--an atypical variant that has not previously been reported in human gastroenteritis. To determine the genetic structure and investigate the origin of this G26P[19] strain, the whole genome of a representative example was characterized, revealing a novel genome constellation: G26-P[19]-I5-R1-C1-M1-A8-N1-T1-E1-H1. The genome segments were most closely related to porcine (VP7, VP4, VP6 and NSP1) and Wa-like porcine RVs (VP1-3 and NSP2-5). We proposed that this G26P[19] strain was the product of zoonotic transmiss..
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Awarded by Wellcome Trust of the UK
Awarded by VIZIONS hospital disease surveillance consortium
Awarded by Royal Society
Awarded by National Health and Medical Research Council of Australia
Awarded by Wellcome Trust
Funding Acknowledgements
We are grateful to all study members at the Hospital for Tropical Diseases (Nguyen Tran Chinh, Ha Vinh and study team at Infectious Pediatric Ward B), Children's Hospital 1 (Tang Chi Thuong, Hoang Le Phuc and study team at Gastrointestinal Ward, and General Planning and Development Department) and Children's Hospital 2 (Ha Manh Tuan, Pham Thi Ngoc Tuyet and study team at Gastrointestinal Ward, Training-Research and International Collaboration Department) in HCMC, Vietnam, for their enthusiastic and active participation in the study and effort in enrolling patients. This work was supported by the Wellcome Trust of the UK, through both core funding (089276/2/09/2) and the VIZIONS hospital disease surveillance consortium (WT/093724/Z/10/Z), and the Australian Agency for International Development (AusAID, Australia), the International Society for Infectious Diseases (Brookline, MA, USA) and the University of Oxford Vice Chancellors' Fund (Oxford, UK). S. B. is a Sir Henry Dale Fellow, jointly funded by the Wellcome Trust and the Royal Society (100087/Z112/Z). C. D. K. is supported by a research fellowship awarded by the National Health and Medical Research Council of Australia (607347). The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the Wellcome Trust or the institutions with which the authors are affiliated or the grantee bodies.