Journal article
Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures
Jennifer Stone, Deborah J Thompson, Isabel dos Santos Silva, Christopher Scott, Rulla M Tamimi, Sara Lindstrom, Peter Kraft, Aditi Hazra, Jingmei Li, Louise Eriksson, Kamila Czene, Per Hall, Matt Jensen, Julie Cunningham, Janet E Olson, Kristen Purrington, Fergus J Couch, Judith Brown, Jean Leyland, Ruth ML Warren Show all
Cancer Research | AMER ASSOC CANCER RESEARCH | Published : 2015
Abstract
Mammographic density measures adjusted for age and body mass index (BMI) are heritable predictors of breast cancer risk, but few mammographic density-associated genetic variants have been identified. Using data for 10,727 women from two international consortia, we estimated associations between 77 common breast cancer susceptibility variants and absolute dense area, percent dense area and absolute nondense area adjusted for study, age, and BMI using mixed linear modeling. We found strong support for established associations between rs10995190 (in the region of ZNF365), rs2046210 (ESR1), and rs3817198 (LSP1) and adjusted absolute and percent dense areas (all P < 10(-5)). Of 41 recently discov..
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Awarded by USA National Cancer Institute
Awarded by Public Health Service from the National Cancer Institute, NIH
Awarded by National Cancer Institute
Awarded by Department of Health and Human Services
Awarded by Department of Health and Human Services (Cancer Center)
Awarded by Norwegian Research Council
Awarded by Norwegian Cancer Society
Awarded by South Eastern Norway Regional Health Authority
Awarded by Public Health Service from the National Cancer Institute, NIH, Department of Health and Human Services
Awarded by NIH
Awarded by Cancer Research UK
Awarded by European Community's Seventh Framework Programme
Awarded by Post-Cancer GWAS initiative (GAME-ON initiative)
Awarded by Department of Defence
Awarded by Medical Research Council
Awarded by National Institute for Health Research
Awarded by National Breast Cancer Foundation
Awarded by The Francis Crick Institute
Awarded by NATIONAL CANCER INSTITUTE
Funding Acknowledgements
ABCFS: J. Stone is a National Breast Cancer Foundation Research Fellow. The Australian Breast Cancer Family Registry (ABCFR; 1992-1995) was supported by the Australian NHMRC, the New South Wales Cancer Council, and the Victorian Health Promotion Foundation (Australia), and by grant UM1CA164920 from the USA National Cancer Institute. The Genetic Epidemiology Laboratory at the University of Melbourne has also received generous support from B. Hovey and Dr. R.W. Brown to whom we are most grateful.BBCC: This study was funded, in part, by the ELAN-Program of the University Hospital Erlangen; Katharina Heusinger was funded by the ELAN program of the University Hospital Erlangen. BBCC was supported, in part, by the ELAN program of the Medical Faculty, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg.EPIC-Norfolk: This study was funded by research program grant funding from Cancer Research UK and the Medical Research Council with additional support from the Stroke Association, British Heart Foundation, Department of Health, Research into Ageing and Academy of Medical Sciences.MCBCS: This study was supported by Public Health Service Grants P50 CA 116201, R01 CA128931, R01 CA128931-S01, R01 CA122340, CCSG P30 CA15083, from the National Cancer Institute, NIH, and Department of Health and Human Services.MCCS: M.C. Southey is a National Health and Medical Research Council Senior Research Fellow and a Victorian Breast Cancer Research Consortium Group Leader. The study was supported by the Cancer Council of Victoria and by the Victorian Breast Cancer Research Consortium.MEC: National Cancer Institute: R37CA054281, R01CA063464, R01CA085265, R25CA090956, R01CA132839.MMHS: This work was supported by grants from the National Cancer Institute, NIH, and Department of Health and Human Services. (R01 CA128931, R01 CA 128931-S01, R01 CA97396, P50 CA116201, and Cancer Center Support Grant P30 CA15083).NBCS: This study has been supported with grants from Norwegian Research Council (#183621/S10 and #175240/S10), The Norwegian Cancer Society (PK80108002, PK60287003), and The Radium Hospital Foundation as well as S-02036 from South Eastern Norway Regional Health Authority.NHS: This study was supported by Public Health Service Grants CA131332, CA087969, CA089393, CA049449, CA98233, CA128931, CA116201, CA122340 from the National Cancer Institute, NIH, Department of Health and Human Services.OOA: study was supported by CA122822 and X01 HG005954 from the NIH; Breast Cancer Research Fund; Elizabeth C. Crosby Research Award, Gladys E. Davis Endowed Fund, and the Office of the Vice President for Research at the University of Michigan. Genotyping services for the OOA study were provided by the Center for Inherited Disease Research (CIDR), which is fully funded through a federal contract from the NIH to The Johns Hopkins University, contract number HHSN268200782096.OFBCR: This work was supported by grant UM1 CA164920 from the USA National Cancer Institute.SASBAC: The SASBAC study was supported by Marit and Hans Rausing's Initiative against Breast Cancer, NIH, Susan Komen Foundation, and Agency for Science, Technology and Research of Singapore (A*STAR).SIBS: SIBS was supported by program grant C1287/A10118 and project grants from Cancer Research UK (grant numbers C1287/8459).COGS grant: Collaborative Oncological Gene-environment Study (COGS) that enabled the genotyping for this study. Funding for the BCAC component is provided by grants from the EU FP7 programme (COGS) and from Cancer Research UK. Funding for the iCOGS infrastructure came from: the European Community's Seventh Framework Programme under grant agreement no 223175 (HEALTH-F2-2009-223175; COGS), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692), the NIH (CA128978) and Post-Cancer GWAS initiative (1U19 CA148537, 1U19 CA148065, and 1U19 CA148112-the GAME-ON initiative), the Department of Defence (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund.