Journal article

Involvement of GPR50 polymorphisms in depression: independent replication in a prospective elderly cohort

Joanne Ryan, Isabelle Carriere, Karen Ritchie, Marie-Laure Ancelin

BRAIN AND BEHAVIOR | WILEY | Published : 2015


INTRODUCTION: Despite the explosion in genetic association studies over the last decade, clearly identified genetic risk factors for depression remain scarce and replication studies are becoming increasingly important. G-protein-coupled receptor 50 (GPR50) has been implicated in psychiatric disorders in a small number of studies, although not consistently. METHODS: Data were obtained from 1010 elderly men and women from the prospective population-based ESPRIT study. Logistic regression and survival models were used to determine whether three common GPR50 polymorphisms were associated with depression prevalence or the incidence of depression over 12-years. The analyses were adjusted for a ran..

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Awarded by Agence Nationale de la Recherche (ANR) Project

Awarded by NHMRC Training (Postdoctoral) Fellowship (Overseas Public Health)

Funding Acknowledgements

The ESPRIT project is financed by the regional government of Languedoc-Roussillon, the Agence Nationale de la Recherche (ANR) Project 07 LVIE 004, and an unconditional grant from Novartis. Joanne Ryan is the holder of an NHMRC Training (Postdoctoral) Fellowship (Overseas Public Health, APP1012735). The funders had no role in the design and conduct of the study; in data collection, management, analysis or interpretation of the data; and were not involved with the writing, preparation, review, or approval of the manuscript.