Journal article
Effects of Hemodiafiltration and High Flux Hemodialysis on Nerve Excitability in End-Stage Kidney Disease
R Arnold, BA Pussell, TJ Pianta, V Grinius, CSY Lin, MC Kiernan, J Howells, MJ Jardine, AV Krishnan
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2013
Abstract
Objectives: Peripheral neuropathy is the most common neurological complication in end-stage kidney disease. While high flux hemodialysis (HFHD) and hemodiafiltration (HDF) have become the preferred options for extracorporeal dialysis therapy, the effects of these treatments on nerve excitability have not yet been examined. Methods: An observational proof-of-concept study of nerve excitability and neuropathy was undertaken in an incident dialysis population (n = 17) receiving either HFHD or HDF. Nerve excitability techniques were utilised to assess nerve ion channel function and membrane potential, in conjunction with clinical assessment and standard nerve conduction studies. A mathematical m..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
RA and TP were each supported by an Australian Postgraduate Award from the University of New South Wales. AK was supported by a Career Development Award from the National Health and Medical Research Council of Australia (grant 568680). MJ was supported by a Jacquot Research Establishment Award. Grant support was provided by the National Health and Medical Research Council of Australia (grant 630425). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.