Journal article

Modelling antiviral treatment to prevent hepatitis C infection among people who inject drugs in Victoria, Australia

Margaret E Hellard, Rebecca Jenkinson, Peter Higgs, Mark A Stoove, Rachel Sacks-Davis, Judy Gold, Matthew Hickman, Peter Vickerman, Natasha K Martin

MEDICAL JOURNAL OF AUSTRALIA | AUSTRALASIAN MED PUBL CO LTD | Published : 2012

Abstract

OBJECTIVES: To develop a mathematical model to project the potential impact of hepatitis C virus (HCV) treatment on HCV infection prevalence among people who inject drugs (PWID). DESIGN AND SETTING: An existing model of HCV transmission among PWID was parameterised using data from Victoria, Australia, including specific parameter estimates of the number of people who are currently active injecting drug users, average duration of injecting, chronic HCV infection prevalence among PWID, annual mortality, and annual HCV treatment rate. We also explored the impact of prevalence uncertainty, program scale-up, and new treatments. MAIN OUTCOME MEASURE: Prevalence of chronic HCV infection among peopl..

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University of Melbourne Researchers

Grants

Awarded by Economic and Social Research Council


Awarded by Medical Research Council


Awarded by National Institute for Health Research


Funding Acknowledgements

Margaret Hellard was supported by a National Health and Medical Research Council (NHMRC) Research Fellowship. Rachel Sacks-Davis was supported by an NHMRC PhD scholarship. Peter Higgs was supported by an NHMRC Research Post Doctoral Fellowship. Natasha Martin was supported by Health Protection Scotland. Peter Vickerman was supported by the Medical Research Council, UK. Rebecca Jenkinson and Mark Stoove were supported by Centre for Research Excellence into Injecting Drug Use Fellowships.