Journal article
Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients
I Magalhaes, K Pingris, C Poitou, S Bessoles, N Venteclef, B Kiaf, L Beaudoin, J Da Silva, O Allatif, J Rossjohn, L Kjer-Nielsen, J McCluskey, S Ledoux, L Genser, A Torcivia, C Soudais, O Lantz, C Boitard, J Aron-Wisnewsky, E Larger Show all
Journal of Clinical Investigation | Published : 2015
DOI: 10.1172/JCI78941
Abstract
Obesity and type 2 diabetes (T2D) are associated with low-grade inflammation, activation of immune cells, and alterations of the gut microbiota. Mucosal-associated invariant T (MAIT) cells, which are innate-like T cells that recognize bacterial ligands, are present in blood and enriched in mucosal and inflamed tissues. Here, we analyzed MAIT cells in the blood and adipose tissues of patients with T2D and/or severe obesity. We determined that circulating MAIT cell frequency was dramatically decreased in both patient groups, and this population was even undetectable in some obese patients. Moreover, in both patient groups, circulating MAIT cells displayed an activated phenotype that was associ..
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Awarded by Direction of Clinical Research (CRC)
Awarded by Fondation pour la Recherche Medicale (FRM)
Awarded by French national program "Investissements d'Avenir"
Awarded by LabEx INFLAMEX
Funding Acknowledgements
We thank all the patients and their physicians, the nurse and technician staff (Rohia Alili) who helped with the study. We are grateful to Yannick Simoni for discussion and Michael Gesnon for technical help. We thank Antoine Soprani, INSERM, UMRS 1138, Geoffroy Saint-Hilaire Clinic, Paris, for providing human AT for in vitro cultures. We thank the Direction of Clinical Research (CRC) for support of this clinical investigation (PHRC 02076 and PHRC microbaria), as well as the Fondation pour la Recherche Medicale (FRM, no. DEQ20140329520 to A. Lehuen and DEQ20120323701 to K. Clement), the National Agency of Research (ANR Fibrota and ObeMAIT projects), the French national program "Investissements d'Avenir" with the reference ANR-10-IAHU-05, the LabEx INFLAMEX with the reference ANR-11-IDEX-0005-02, and Departement Hospitalo-Universitaire (DHU) AutHors (Autoimmune and Hormonal Diseases).