Journal article

Treatment of face and scalp solar (actinic) keratosis with daylight-mediated photodynamic therapy is possible throughout the year in Australia: Evidence from a clinical and meteorological study

Lynda Spelman, Diana Rubel, Dedee F Murrell, Jo-Ann See, Daniel Hewitt, Peter Foley, Robert Salmon, Delphine Kerob, Thierry Pascual, Stephen Shumack, Pablo Fernandez-Penas

AUSTRALASIAN JOURNAL OF DERMATOLOGY | WILEY-BLACKWELL | Published : 2016

Abstract

BACKGROUND/OBJECTIVES: Solar (actinic) keratosis (AK) is an emergent concern worldwide and is associated with an increased risk of development of non-melanoma skin cancer, especially squamous cell carcinoma. Daylight-mediated photodynamic therapy (DL-PDT) using methyl aminolaevulinate cream has proved to be an effective, nearly painless, and more convenient alternative to conventional PDT for the treatment of AK. In a phase III, randomised, controlled trial performed in Australia, the mean irradiance (light intensity) received by patients during DL-PDT treatment, assessed via a spectroradiometer, was 305 W/m(2) (min. 40 to max. 585 W/m(2) ) with similar efficacy irrespective of intensity or ..

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