Repetitive concussions in adolescent athletes - translating clinical and experimental research into perspectives on rehabilitation strategies
Bridgette D Semple, Sangmi Lee, Raha Sadjadi, Nora Fritz, Jaclyn Carlson, Carrie Griep, Vanessa Ho, Patrice Jang, Annick Lamb, Beth Popolizio, Sonia Saini, Jeffrey J Bazarian, Mayumi L Prins, Donna M Ferriero, D Michele Basso, Linda J Noble-Haeusslein
FRONTIERS IN NEUROLOGY | FRONTIERS MEDIA SA | Published : 2015
Sports-related concussions are particularly common during adolescence, a time when even mild brain injuries may disrupt ongoing brain maturation and result in long-term complications. A recent focus on the consequences of repetitive concussions among professional athletes has prompted the development of several new experimental models in rodents, as well as the revision of guidelines for best management of sports concussions. Here, we consider the utility of rodent models to understand the functional consequences and pathobiology of concussions in the developing brain, identifying the unique behavioral and pathological signatures of concussive brain injuries. The impact of repetitive concuss..View full abstract
Awarded by National Institutes of Health
Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
The authors would like to thank Shannon and Dennis Wong for their generous financial support. The authors' work is also supported by the National Institutes of Health grants NS050159 (LN), NS077767 (LN) and NS074882 (DB), and a CJ Martin Overseas Biomedical Postdoctoral Fellowship from the National Health and Medical Research Council of Australia (BS).