Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species.
Bridgette D Semple, Klas Blomgren, Kayleen Gimlin, Donna M Ferriero, Linda J Noble-Haeusslein
Prog Neurobiol | Published : 2013
Hypoxic-ischemic and traumatic brain injuries are leading causes of long-term mortality and disability in infants and children. Although several preclinical models using rodents of different ages have been developed, species differences in the timing of key brain maturation events can render comparisons of vulnerability and regenerative capacities difficult to interpret. Traditional models of developmental brain injury have utilized rodents at postnatal day 7-10 as being roughly equivalent to a term human infant, based historically on the measurement of post-mortem brain weights during the 1970s. Here we will examine fundamental brain development processes that occur in both rodents and huma..View full abstract
Awarded by NINDS NIH HHS