Journal article

Deficits in social behavior emerge during development after pediatric traumatic brain injury in mice.

Bridgette D Semple, Sandra A Canchola, Linda J Noble-Haeusslein

J Neurotrauma | Published : 2012

Abstract

The pediatric brain may be particularly vulnerable to social deficits after traumatic brain injury (TBI) due to the protracted nature of psychosocial development through adolescence. However, the majority of pre-clinical studies fail to assess social outcomes in experimental pediatric TBI. The current study evaluated social behavior in mice subjected to TBI at post-natal day (p)21. Social behaviors were assessed by a partition test, resident-intruder, three-chamber, and tube dominance tasks during adolescence (p35-42) and again during early adulthood (p60-70), during encounters with unfamiliar, naïve stimulus mice. Despite normal olfactory function and normal social behaviors during adolesce..

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