Journal article

Febrile seizures and generalized epilepsy associated with a mutation in the Na -channel beta 1 subunit gene SCN1B

RH Wallace, DW Wang, R Singh, IE Scheffer, AL George, HA Phillips, K Saar, A Reis, EW Johnson, GR Sutherland, SF Berkovic, JC Mulley

NATURE GENETICS | NATURE AMERICA INC | Published : 1998

Abstract

Febrile seizures affect approximately 3% of all children under six years of age and are by far the most common seizure disorder. A small proportion of children with febrile seizures later develop ongoing epilepsy with afebrile seizures. Segregation analysis suggests the majority of cases have complex inheritance but rare families show apparent autosomal dominant inheritance. Two putative loci have been mapped (FEB1 and FEB2), but specific genes have not yet been identified. We recently described a clinical subset, termed generalized epilepsy with febrile seizures plus (GEFS+), in which many family members have seizures with fever that may persist beyond six years of age or be associated with..

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