REGENERATION OF GASTRIC-MUCOSA AFTER ASPIRIN-INDUCED INJURY IN RAT

Abstract

Regeneration of gastric mucosa damaged by aspirin was studied in 6-week-old rats, using histologic and autoradiographic technics. Aspirin (120 mg/kg) was given by esophageal intubation either in a single dose or each day for 14 days. After a single dose, two types of lesion were observed in the mucosa of the body of the stomach: (a) superficial erosions which were already present after 30 minutes and which completely healed within 24 hours; (b) deeper erosions, reaching maximal numbers at 4 hours, which healed slowly with a median disappearance time of 5 days and which were associated with a focal increase in3H-thymidine-labeled cells. The peak increase in labeling occurred between 16 and 48..