Chronic gastric ulcer induced by aspirin: an experimental model

Abstract

Investigations were performed in the rat to examine the effects of prolonged administration of aspirin on the gastric mucosa. Groups of rats received aspirin by esophageal intubation in doses of 120, 250, or 500 mg/kg per day for 6 mth. Chronic gastric ulcers were found in the antral mucosa in 9 of 16 rats given 250 or 500 mg/kg per day of aspirin. In addition, there were multiple erosions in the glandular mucosa in all of the aspirin treated rats surviving the treatment period. In a control group, gastric histology was normal in every instance. Mucosal recovery was virtually complete in rats in the 120 and 250 mg/kg groups allowed to survive for an additional 3 weeks, without aspirin; but i..