Journal article

Local ganglion cell contributions to the macaque electroretinogram revealed by experimental nerve fiber layer bundle defect.

Brad Fortune, Lin Wang, Bang V Bui, Grant Cull, Jin Dong, George A Cioffi

Invest Ophthalmol Vis Sci | Published : 2003

Abstract

PURPOSE: To assess the structural and functional consequences of local ganglion cell (GC) loss in an experimental model of a retinal nerve fiber layer (NFL) bundle defect. To evaluate and compare three commonly used multifocal electroretinogram (mfERG) stimuli, as well as the standard transient pattern-reversal ERG (pERG) and the photopic full-field ERG, for detection of local GC damage. METHODS: Intraretinal axotomy was achieved by multiple treatments with a diode laser adapted to a slit lamp biomicroscope. Retinal laser burns were applied along an arc, subtending approximately 60 degrees, about one disc diameter superotemporal to the optic nerve. Functional measures were acquired before la..

View full abstract

University of Melbourne Researchers