Journal article

Local ganglion cell contributions to the macaque electroretinogram revealed by experimental nerve fiber layer bundle defect.

Brad Fortune, Lin Wang, Bang V Bui, Grant Cull, Jin Dong, George A Cioffi

Invest Ophthalmol Vis Sci | Published : 2003


PURPOSE: To assess the structural and functional consequences of local ganglion cell (GC) loss in an experimental model of a retinal nerve fiber layer (NFL) bundle defect. To evaluate and compare three commonly used multifocal electroretinogram (mfERG) stimuli, as well as the standard transient pattern-reversal ERG (pERG) and the photopic full-field ERG, for detection of local GC damage. METHODS: Intraretinal axotomy was achieved by multiple treatments with a diode laser adapted to a slit lamp biomicroscope. Retinal laser burns were applied along an arc, subtending approximately 60 degrees, about one disc diameter superotemporal to the optic nerve. Functional measures were acquired before la..

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University of Melbourne Researchers