Journal article

Prior antibacterial peptide-mediated inhibition of protein folding in bacteria mutes resistance enzymes

Laszlo Otvos, Vanessa de Olivier Inacio, John D Wade, Predrag Cudic

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | AMER SOC MICROBIOLOGY | Published : 2006

Abstract

The antimicrobial activity of amoxicillin against TEM-1-expressing strains could be fully recovered when bacteria were preincubated with sublethal doses of an antibacterial peptide derivative. Assays with the simultaneous administration of antibiotics or synergy assays with kanamycin or ciprofloxacin, where resistance development does not involve properly folded proteins, failed to yield similar results.