Prior antibacterial peptide-mediated inhibition of protein folding in bacteria mutes resistance enzymes
Laszlo Otvos, Vanessa de Olivier Inacio, John D Wade, Predrag Cudic
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | AMER SOC MICROBIOLOGY | Published : 2006
The antimicrobial activity of amoxicillin against TEM-1-expressing strains could be fully recovered when bacteria were preincubated with sublethal doses of an antibacterial peptide derivative. Assays with the simultaneous administration of antibiotics or synergy assays with kanamycin or ciprofloxacin, where resistance development does not involve properly folded proteins, failed to yield similar results.