Journal article

T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules

Jamie Rossjohn, Stephanie Gras, John J Miles, Stephen J Turner, Dale I Godfrey, James McCluskey, DR Littman (ed.), WM Yokoyama (ed.)

ANNUAL REVIEW OF IMMUNOLOGY VOL 33 | ANNUAL REVIEWS | Published : 2015

Abstract

The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is ideally suited to capture and present an array of peptide antigens (Ags). In addition, the CD1 family members and MR1 are MHC class I-like molecules that bind lipid-based Ags and vitamin B precursors, respectively. These Ag-bound molecules are subsequently recognized by T cell antigen receptors (TCRs) expressed on the surface of T lymphocytes. Structural and associated functional studies have been highly informative in providing insight into these interactions, which are crucial to immunity, and how they can lead to..

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