Macrocyclic N-methylated cyclic peptides and depsipeptides

Abstract

Marine microorganisms and fungi are sources of cyclopeptides and cyclodepsipeptides that have numerous biological activities including antifungal, immunosuppressive, and anticancer. Some have been through clinical trials including didemnin B discussed in this review. These interesting properties of cyclopeptides and cyclodepsipeptides have resulted in a huge increase in research activity in the last few years. In this review, discussion of four families and some miscellaneous cyclopeptides and cyclodepsipeptides is presented.Aureobasidins (Abs) are the first group discussed. The isolation protocol of the Abs from the yeast-like fungus, Aureobasidium pullulans, structural characterization, an..