Journal article
Blood-based protein biomarker panel for the detection of colorectal cancer
KYC Fung, B Tabor, MJ Buckley, IK Priebe, L Purins, C Pompeia, GV Brierley, T Lockett, P Gibbs, J Tie, P McMurrick, J Moore, A Ruszkiewicz, E Nice, TE Adams, A Burgess, LJ Cosgrove
Plos One | Published : 2015
Abstract
Background: The majority of colorectal cancer (CRC) cases are preventable by early detection and removal of precancerous polyps. Even though CRC is the second most common internal cancer in Australia, only 30 per cent of the population considered to have risk factors participate in stool-based test screening programs. Evidence indicates a robust, blood-based, diagnostic assay would increase screening compliance. A number of potential diagnostic bloodbased protein biomarkers for CRC have been reported, but all lack sensitivity or specificity for use as a stand-alone diagnostic. The aim of this study was to identify and validate a panel of protein-based biomarkers in independent cohorts that c..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was funded by the CSIRO Preventative Health National Research Flagship and the National Health and Medical Research Council (grant number 1017078) (https://www.nhmrc.gov.au/) to LJC. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.