Proprotein convertase 5/6 cleaves platelet-derived growth factor A in the human endometrium in preparation for embryo implantation
Sarah Paule, Thomas Nebl, Andrew I Webb, Beverley Vollenhoven, Luk JF Rombauts, Guiying Nie
Molecular Human Reproduction | OXFORD UNIV PRESS | Published : 2015
Establishment of endometrial receptivity is vital for successful embryo implantation. Proprotein convertase 5/6 (referred to as PC6) is up-regulated in the human endometrium specifically at the time of epithelial receptivity. PC6, a serine protease of the proprotein convertase family, plays an important role in converting precursor proteins into their active forms through specific proteolysis. The proform of platelet-derived growth factor A (pro-PDGFA) requires PC cleavage to convert to the active-PDGFA. We investigated the PC6-mediated activation of PDGFA in the human endometrium during the establishment of receptivity. Proteomic analysis identified that the pro-PDGFA was increased in the c..View full abstract
Awarded by National Health and Medical Research Council of Australia
This work was supported by the National Health and Medical Research Council of Australia [Project grant #1044182 and Fellowship #1041835 (to G.N.)] and Monash IVF, the Victorian Government Operational Infrastructure Support Program.