Journal article
Modulating effects of WT1 on interferon-β-vitamin D association in MS
R Lin, BV Taylor, J Charlesworth, I van der Mei, L Blizzard, N Stewart, AL Ponsonby, T Dwyer, F Pittas, J Simpson
Acta Neurologica Scandinavica | WILEY | Published : 2015
DOI: 10.1111/ane.12315
Abstract
Objective: To investigate whether those genes involved in the vitamin D pathway modulate the relationship between 25-hydroxyvitamin D (25(OH)D) and IFN-β, the relationship between IFN-β and sun in predicting 25(OH)D, and the interaction between IFN-β and 25(OH)D in modulating relapse risk in patients with MS. Methods: Prospective cohort study of 169 participants with MS and genotype data followed 2002-2005. Gene-IFN-β and gene-IFN-β-sun interactions predicting 25(OH)D evaluated by multilevel mixed-effects linear regression. Gene-IFN-β interactions with 25(OH)D in modulating in relapse risk assessed using survival analysis. Results: The cohort was 71.6% female and of mean age 47.8. Two-indepe..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The MS Longitudinal Study was funded by a grant from the National Health and Medical Research Council (NHMRC) of Australia (Project 333105). SSJ is supported by a Multiple Sclerosis Research Australia Postdoctoral Research Fellowship. IvM is supported by an Australian Research Council Future Fellowship. A-L.P. is supported by an NHMRC Senior Research Fellowship.