Journal article

Infantile haemangiomas that failed treatment with propranolol: Clinical and histopathological features

Roderic J Phillips, Zerina Lokmic, Catherine M Crock, Anthony Penington

JOURNAL OF PAEDIATRICS AND CHILD HEALTH | WILEY | Published : 2014

Abstract

AIM: To describe the clinical and histopathological characteristics of infantile haemangiomas that failed treatment with oral propranolol . DESIGN: This study is a case series from the vascular birthmarks clinic at Royal Children's Hospital, Melbourne. PATIENTS: The patients for this study were infants who commenced treatment with oral propranolol before 6 months of age and who were treated for at least 4 months without a satisfactory result. For histology and immunohistochemistry, tissue from the four non-responding patients who subsequently underwent surgical excision was matched with four historical controls. OUTCOME MEASURES: Based on medical record review and photographic assessments, i..

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