Infantile haemangiomas that failed treatment with propranolol: Clinical and histopathological features

Abstract

Aim: To describe the clinical and histopathological characteristics of infantile haemangiomas that failed treatment with oral propranolol. Design: This study is a case series from the vascular birthmarks clinic at Royal Children's Hospital, Melbourne. Patients: The patients for this study were infants who commenced treatment with oral propranolol before 6 months of age and who were treated for at least 4 months without a satisfactory result. For histology and immunohistochemistry, tissue from the four non-responding patients who subsequently underwent surgical excision was matched with four historical controls. Outcome measures: Based on medical record review and photographic assessments, in..