Early cartilage abnormalities at the hip are associated with obesity and body composition measures - a 3.0T MRI community-based study
Andrew J Teichtahl, Yuanyuan Wang, Sam Smith, Anita Wluka, Donna Urquhart, Graham G Giles, Sultana Monira Hussain, Flavia M Cicuttini
ARTHRITIS RESEARCH & THERAPY | BMC | Published : 2015
INTRODUCTION: Although obesity is a risk factor for hip osteoarthritis (OA), the role of body composition, if any, is unclear. This study examines whether the body mass index (BMI) and body composition are associated with hip cartilage changes using magnetic resonance imaging (MRI) in community-based adults. METHODS: 141 community-based participants with no clinical hip disease, including OA, had BMI and body composition (fat mass and fat free mass) measured at baseline (1990 to 1994), and BMI measured and 3.0 T MRI performed at follow-up (2009-2010). Femoral head cartilage volume was measured and femoral head cartilage defects were scored in the different hip regions. RESULTS: For females, ..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC)
Awarded by NHMRC
The Melbourne Collaborative Cohort Study recruitment was funded by VicHealth and The Cancer Council of Victoria. This study was funded by a program grant from the National Health and Medical Research Council (NHMRC; 209057) and was further supported by infrastructure provided by The Cancer Council of Victoria. This current hip MRI study was supported by Arthritis Australia. AJT is the recipient of the NHMRC Early Career Fellowship (# 1073284). WY, AEW and DU are the recipients of NHMRC Career Development Fellowship (Clinical Level 1 # 1065464, Clinical Level 2 # 1063574 and Clinical Level 1 # 1011975, respectively).