Journal article
The surgically remediable syndrome of epilepsy associated with bottom-of-sulcus dysplasia
AS Harvey, SA Mandelstam, WJ Maixner, RJ Leventer, M Semmelroch, D MacGregor, RM Kalnins, Y Perchyonok, GJ Fitt, S Barton, MJ Kean, GCA Fabinyi, GD Jackson
Neurology | Published : 2015
Abstract
To determine clinical and EEG features that might help identify patients with epilepsy harboring small, intrinsically epileptogenic, surgically treatable, bottom-of-sulcus dysplasias (BOSDs). Methods: Retrospective review of clinical records, EEG, MRI, and histopathology in 32 patients with drug-resistant epilepsy and MRI-positive (72% 3.0 tesla), pathologically proven (type 2B cortical dysplasia) BOSDs operated at our centers during 2005-2013. Results: Localization of BOSDs was frontal in 19, insula in 5, parietal in 5, and temporal in 3, on the convexity or interhemispheric surfaces. BOSDs were missed on initial MRI at our centers in 22% of patients. Patients presented with focal seizures ..
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Awarded by Royal Children's Hospital Foundation
Funding Acknowledgements
A. Harvey and S. Mandelstam report no disclosures relevant to the manuscript. W. Maixner receives royalties from Springer-Verlag for the books Pediatric Hydrocephalus and Spina Bifida. R. Leventer, M. Semmelroch, D. MacGregor, R. Kalnins, Y. Perchyonok, and G. Fitt report no disclosures relevant to the manuscript. S. Barton was supported by RCH1000, a unique arm of The Royal Children's Hospital Foundation devoted to raising funds for research at The Royal Children's Hospital. M. Kean reports no disclosures relevant to the manuscript. G. Fabinyi is section editor of ANZ Journal of Surgery. G. Jackson has received honoraria from UCB Pharma and receives royalties from Elsevier for the book Magnetic Resonance in Epilepsy. Go to Neurology.org for full disclosures.