Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax
C Hockings, K Anwari, RL Ninnis, J Brouwer, M O'Hely, M Evangelista, MG Hinds, PE Czabotar, EF Lee, WD Fairlie, G Dewson, RM Kluck
Cell Death & Disease | NATURE PUBLISHING GROUP | Published : 2015
Awarded by National Health and Medical Research Council of Australia
Awarded by Association for International Cancer Research
Awarded by Worldwide Cancer Research
We thank Jerry Adams for critical reading of the manuscript; Stephanie Fennell, Tobias Kratina and Ahmad Wardak for technical assistance; Adeline Robin and Michael Roy for recombinant proteins; David Huang for ABT-737. The work was supported by grants from the National Health and Medical Research Council of Australia (no. 575559, no. 1016701 and no. 1041936), and the Association for International Cancer Research (no. 10-230), and operational infrastructure grants through the Victorian State Government Operational Infrastructure Support and the Australian Government NHMRC IRIISS.