The prediction of type 2 diabetes in women with previous gestational diabetes mellitus using lipidomics

M Lappas; PA Mundra; G Wong; K Huynh; D Jinks; HM Georgiou; M Permezel; PJ Meikle

Journal article

The prediction of type 2 diabetes in women with previous gestational diabetes mellitus using lipidomics

M Lappas, PA Mundra, G Wong, K Huynh, D Jinks, HM Georgiou, M Permezel, PJ Meikle

Diabetologia | Published : 2015

DOI: 10.1007/s00125-015-3587-7

Abstract

Aims/hypothesis: The risk of developing diabetes is greater for women with previous gestational diabetes mellitus (GDM). In the general population, plasma lipidomic analysis can identify individuals at risk of developing type 2 diabetes. The aim of this study was to determine whether circulating lipid levels 12 weeks following a GDM pregnancy were associated with an increased risk of developing type 2 diabetes. Methods: Plasma lipid profiles containing >300 lipids were measured in 104 normal glucose-tolerant women 12 weeks following an index GDM pregnancy using electrospray-ionisation tandem mass spectrometry. Women were assessed for 10 years for development of overt type 2 diabetes. Results..

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University of Melbourne Researchers

Martha Lappas Author

Kevin Huynh Author

Harry Georgiou Author

Michael Permezel Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

ML is supported by a Career Development Fellowship from the National Health and Medical Research Council (NHMRC) of Australia (grant no. 1047025). PJM is supported by a NHMRC Senior Research Fellowship (grant no. 1042095). The work described in this manuscript was funded by the Medical Research Foundation for Women and Babies (ML, HMG), NHMRC of Australia (PJM) and the OIS Program of the Victorian Government, Australia (PJM).