Journal article

The prediction of type 2 diabetes in women with previous gestational diabetes mellitus using lipidomics

Martha Lappas, Piyushkumar A Mundra, Gerard Wong, Kevin Huynh, Debra Jinks, Harry M Georgiou, Michael Permezel, Peter J Meikle

DIABETOLOGIA | SPRINGER | Published : 2015

Abstract

AIMS/HYPOTHESIS: The risk of developing diabetes is greater for women with previous gestational diabetes mellitus (GDM). In the general population, plasma lipidomic analysis can identify individuals at risk of developing type 2 diabetes. The aim of this study was to determine whether circulating lipid levels 12 weeks following a GDM pregnancy were associated with an increased risk of developing type 2 diabetes. METHODS: Plasma lipid profiles containing >300 lipids were measured in 104 normal glucose-tolerant women 12 weeks following an index GDM pregnancy using electrospray-ionisation tandem mass spectrometry. Women were assessed for 10 years for development of overt type 2 diabetes. RESULTS..

View full abstract