Journal article

Ocular motor measures of cognitive dysfunction in multiple sclerosis I: inhibitory control

Meaghan Clough, Lynette Millist, Nathaniel Lizak, Shin Beh, Teresa C Frohman, Elliot M Frohman, Owen B White, Joanne Fielding



Our ability to control and inhibit behaviours that are inappropriate, unsafe, or no longer required is crucial for functioning successfully in complex environments. Here, we investigated whether a series of ocular motor (OM) inhibition tasks could dissociate deficits in patients with multiple sclerosis (MS), including patients with only a probable diagnosis (clinically isolated syndrome: CIS), from healthy individuals as well as a function of increasing disease duration. 25 patients with CIS, 25 early clinically definite MS patients (CDMS: ≤7 years of diagnosis), 24 late CDMS patients (>7 years from diagnosis), and 25 healthy controls participated. All participants completed a series of clas..

View full abstract


Funding Acknowledgements

We would like to thank all the participants who gave up their time and conscientiously completed each task. We would also like to thank Bayer, Australia for providing the financial support for this study. This study was funded by Bayer, Australia. The authors are deeply grateful to Mr. Jason Thean Kit Ooi, for his patience, dedication, perseverance, and hard work on the creation of the medical illustrations contained within this two-part series on cognitive abnormalities in MS.