Journal article

Label-free screening of single biomolecules through resistive pulse sensing technology for precision medicine applications

S Harrer, SC Kim, C Schieber, S Kannam, N Gunn, S Moore, D Scott, R Bathgate, S Skafidas, JM Wagner

NANOTECHNOLOGY | IOP PUBLISHING LTD | Published : 2015

Abstract

Employing integrated nano- and microfluidic circuits for detecting and characterizing biological compounds through resistive pulse sensing technology is a vibrant area of research at the interface of biotechnology and nanotechnology. Resistive pulse sensing platforms can be customized to study virtually any particle of choice which can be threaded through a fluidic channel and enable label-free single-particle interrogation with the primary read-out signal being an electric current fingerprint. The ability to perform label-free molecular screening with single-molecule and even single binding site resolution makes resistive pulse sensing technology a powerful tool for analyzing the smallest u..

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