Journal article

Conformational rearrangements of RIG-I receptor on formation of a multiprotein:dsRNA assembly.

Simone A Beckham, Jason Brouwer, Anna Roth, Die Wang, Anthony J Sadler, Matthias John, Kerstin Jahn-Hofmann, Bryan RG Williams, Jacqueline A Wilce, Matthew CJ Wilce

Nucleic Acids Res | Published : 2013

Abstract

The retinoic acid inducible gene-I (RIG-I)-like family of receptors is positioned at the front line of our innate cellular defence system. RIG-I detects and binds to foreign duplex RNA in the cytoplasm of both immune and non-immune cells, and initiates the induction of type I interferons and pro-inflammatory cytokines. The mechanism of RIG-I activation by double-stranded RNA (dsRNA) involves a molecular rearrangement proposed to expose the N-terminal pair of caspase activation recruitment domains, enabling an interaction with interferon-beta promoter stimulator 1 (IPS-1) and thereby initiating downstream signalling. dsRNA is particularly stimulatory when longer than 20 bp, potentially throug..

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University of Melbourne Researchers