Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance

Con Dogovski; Stanley C Xie; Gaetan Burgio; Jess Bridgford; Sachel Mok; James M McCaw; Kesinee Chotivanich; Shannon Kenny; Nina Gnaedig; Judith Straimer; Zbynek Bozdech; David A Fidock; Julie A Simpson; Arjen M Dondorp; Simon Foote; Nectarios Klonis; Leann Tilley

Journal article

Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance

Con Dogovski, Stanley C Xie, Gaetan Burgio, Jess Bridgford, Sachel Mok, James M McCaw, Kesinee Chotivanich, Shannon Kenny, Nina Gnaedig, Judith Straimer, Zbynek Bozdech, David A Fidock, Julie A Simpson, Arjen M Dondorp, Simon Foote, Nectarios Klonis, Leann Tilley

PLOS BIOLOGY | PUBLIC LIBRARY SCIENCE | Published : 2015

DOI: 10.1371/journal.pbio.1002132

Download PDF

University of Melbourne Researchers

Jessica Bridgford Author Medical Biology (W.E.H.I.)

Leann Tilley Author Biochemistry and Pharmacology

James McCaw Author Mathematics and Statistics

Stanley Xie Author Biochemistry and Pharmacology

Julie Simpson Author Melbourne School of Population and Global Health

Related Projects (3)

NOVEL FLUORESCENT PROBES OF CELLULAR MICROENVIRONMENTS TO STUDY THE MECHANISM OF ACTION OF ENDOPEROXIDE ANTIMALARIALS

Malaria is responsible for the deaths of about two million children each year. As current drugs become increasingly useless due to the devel..

PROBING SEXUAL TRANSFORMATION OF THE HUMAN MALARIA PARASITE,PLASMODIUM FALCIPARUM,USING NOVEL IMAGING MODALITIES

Malaria parasites adopt a characteristic banana shape prior to sexual recombination; without this shape change disease transmission via mosq..

ARC CENTRE OF EXCELLENCE IN COHERENT X-RAY SCIENCE

Grants

Awarded by National Health & Medical Research Council of Australia

Awarded by Australia Research Council

Awarded by Singapore National Medical Council

Awarded by National Institutes of Health, USA

Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

Funding Acknowledgements

This work was supported by the National Health & Medical Research Council of Australia (Grant#541904), the Australia Research Council (Grants: CE0561787 & DP110100624), the Singapore National Medical Council (NMRC/1265/2010), and National Institutes of Health, USA (R01 AI109023, to DAF). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.