Journal article
Intra-individual variability in prodromal Huntington disease and its relationship to genetic burden
M Musso, HJ Westervelt, JD Long, E Morgan, SP Woods, MM Smith, W Lu, JS Paulsen, S Cross, P Ryan, EA Epping, E Chiu, J Preston, A Goh, S Antonopoulos, S Loi, P Chua, A Komiti, L Raymond, J Decolongon Show all
Journal of the International Neuropsychological Society | Published : 2015
Abstract
The current study sought to examine the utility of intra-individual variability (IIV) in distinguishing participants with prodromal Huntington disease (HD) from nongene-expanded controls. IIV across 15 neuropsychological tasks and within-task IIV using a self-paced timing task were compared as a single measure of processing speed (Symbol Digit Modalities Test [SDMT]) in 693 gene-expanded and 191 nongene-expanded participants from the PREDICT-HD study. After adjusting for depressive symptoms and motor functioning, individuals estimated to be closest to HD diagnosis displayed higher levels of across- and within-task variability when compared to controls and those prodromal HD participants far ..
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Awarded by National Center for Advancing Translational Sciences
Funding Acknowledgements
This work was supported by the National Institutes of Health, National Institute of Neurological Disorders and Stroke (J.S. Paulsen, grant number NS040068), CHDI Foundation, Inc (J.S. Paulsen, grant number A3917), Cognitive and Functional Brain Changes in Preclinical Huntington's Disease (HD) (J.S. Paulsen, grant number 5R01NS054893), 4D Shape Analysis for Modeling Spatiotemporal Change Trajectories in Huntington's (grant number 1U01NS082086), Functional Connectivity in Premanifest Huntington's Disease (grant number 1U01NS082083), and Basal Ganglia Shape Analysis and Circuitry in Huntington's Disease (grant number 1U01NS082085).