Transcriptional analysis identifies key genes involved in metabolism, fibrosis/tissue repair and the immune response against Fasciola hepatica in sheep liver
Cristian A Alvarez Rojas, Brendan RE Ansell, Ross S Hall, Robin B Gasser, Neil D Young, Aaron R Jex, Jean-Pierre Y Scheerlinck
Parasites and Vectors | BMC | Published : 2015
BACKGROUND: Although fascioliasis has been relatively well studied, little is known about the molecular basis of this disease. This is particularly relevant, considering the very different response that sheep have to Fasciola hepatica relative to cattle. The acute phase of this disease is severe in sheep, whereas chronic fascioliasis is more common in cattle. METHODS: To begin to explore the host-response to Fasciola in sheep and improve the understanding of the host-pathogen interactions during the parasite's migration through liver parenchyma to the bile duct, we used RNA sequencing (RNA-seq) to investigate livers from sheep infected for eight weeks compared with those from uninfected cont..View full abstract
Awarded by Victorian Life Sciences Computation Initiative (VLSCI)
This work was supported by the Australian Research Council and (ARC) and the National Health and Medical Research Council (NHMRC) of Australia as well as by a Victorian Life Sciences Computation Initiative (VLSCI) grant number VR0007 on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government.