Journal article

Growth axis maturation is linked to nutrition, growth and developmental rate

Jennifer A Hetz, Brandon R Menzies, Geoffrey Shaw, Alexandra Rao, Lain J Clarke, Marilyn B Renfree

MOLECULAR AND CELLULAR ENDOCRINOLOGY | ELSEVIER IRELAND LTD | Published : 2015

Abstract

Maturation of the mammalian growth axis is thought to be linked to the transition from fetal to post-natal life at birth. However, in an altricial marsupial, the tammar wallaby (Macropus eugenii), this process occurs many months after birth but at a time when the young is at a similar developmental stage to that of neonatal eutherian mammals. Here we manipulate growth rates and demonstrate in slow, normal and fast growing tammar young that nutrition and growth rate affect the time of maturation of the growth axis. Maturation of GH/IGF-I axis components occurred earlier in fast growing young, which had significantly increased hepatic GHR, IGF1 and IGFALS expression, plasma IGF-I concentration..

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Grants

Awarded by Australian Research Council Discovery Outstanding Researcher Award


Awarded by Centenary Fellowship and Early Career Researcher Grant from the University of Melbourne


Funding Acknowledgements

We thank Chris Goddard for his assistance with the development of a sandwich ELISA for tammar wallaby IGF-I. We also thank all the members of the Wallaby Research Group and especially Scott Brownlees for assistance with the animal handling and measurements. This work was supported by an Australian Research Council (DP120101797) Discovery Outstanding Researcher Award to MBR, a Centenary Fellowship and Early Career Researcher Grant from the University of Melbourne (501392) to BRM and the Programa de Formacion de Capital Humano Avanzado to JAH.